L-Citrulline is one of the three dietary amino acids in the urea cycle, alongside L-arginine and L-ornithine. It’s used as a cardiovascular health and sports performance nutritional supplement.
Supplementing with L-citrulline has been shown to increase both ornithine and arginine plasma content, which means that L-citrulline supplementation improves the ammonia recycling process and nitric oxide metabolism. By boosting nitric oxide production in the body it improves blood flow as a vasodilator and induces greater flexibility in the walls of blood cells. These functions support improved physical endurance, lower blood pressure, and reduced erectile dysfunction.