MicroPQQ®

Sustained release pyrroloquinoline quinone

An organic molecule naturally occurring in the food supply, PQQ is considered by some to be the first new vitamin discovered since 1948. It supports the health of the mitochondria, which generate the energy human cells need to function efficiently*

Microactive PQQ Benefits Proven in Research

Microactive PQQ delivers the natural brand of PQQ in a special micronized, sustained-release matrix. Because the PQQ is released over time, it stays in the blood longer — and so is active longer — than regular PQQ.

In fact, a comparative human case study showed that MicroPQQ is 2.2x more bioavailable than regular PQQ and delivers more than a 9-hour sustained release.

Since the degradation of mitochondria is a key contributing factor in physiological aging, Microactive PQQ may slow this process and increase energy levels.

Since the degradation of mitochondria is a key contributing factor to physiological aging, MicroPQQ® may slow the aging process and increase energy levels.* Scientific research has shown that PQQ:

• Protects nerve cells*

• Improves cognitive function*

• Alleviates occasional stress and sleeplessness*

• Double-blind, placebo-controlled human studies have also found PQQ improves spatial awareness, short-term memory, and concentration.*

MicroPQQ® delivers the natural brand of PQQ in a special micronized, sustained-release matrix. Because the PQQ is released over time, it stays in the blood longer — and is therefore active longer — than regular PQQ. The results of a dissolution study and a pilot clinical study found that MicroPQQ® demonstrated:

• Sustained release for over 9 hours

• Multistage release in the stomach and small intestine

• Increased residence time

• 2.2x more bioavailability than standard PQQ

In a dissolution test, the dissolution profile shows a sustained release of PQQ from the MicroActive® formulation. By 121 minutes, 95% of the dose was in solution in a micronized form, with less than a 10-micron particle size. With the control PQQ powder, 100% of the dose was in solution by 360 minutes. The MicroActive® formulation may enhance the beneficial effects in vivo by enabling the serum levels to be maintained for a longer time.

In a bioavailability clinical study, the uptake of PQQ from MicroPQQ® reached a maximum blood level at 2 hours, followed by sustained release for up to 9 hours. The plasma levels remained high at 9 hours, indicating a sustained release longer than 9 hours. In contrast, the control PQQ powder showed a maximum blood level at 2 hours and the plasma level was back to base line by 9 hours. The average area under the curve for MicroPQQ® was 69.66, whereas the control PQQ was less than half as much, with a value of 31.41. The ratio of the area under the curve (sustained plasma concentrations) of MicroActive® to the control PQQ was 2.2 times higher.

MicroPQQ® Product Specifications:

50% PQQ
PQQ in a sustained-release matrix
Reddish-brown powder
Shelf life of 2 years
Suitable for capsules and tablets